The Power Duo: Unraveling the Benefits of Comprehensive Platelet Rich Plasma with Prolotherapy in Chondromalacia Patella

The Power Duo: Unraveling the Benefits of Comprehensive Platelet Rich Plasma with Prolotherapy in Chondromalacia Patella


Chondromalacia patella, commonly known as runner’s  or jumper’s knee, is a condition characterized by the softening and deterioration of the cartilage beneath the patella (kneecap). It is a prevalent issue among athletes and individuals who engage in repetitive knee movements. Chondromalacia is deemed to be a precursor of arthritis as the cartilage breakdown makes for a favourable environment  for arthritis to set in. While traditional treatments like rest, physical therapy, and anti-inflammatory medications can provide relief and are used as a first line treatment for the same,

Comprehensive Platelet Rich Plasma (PRP)² with Prolotherapy has emerged as a promising therapeutic approach to accelerate healing and enhance recovery for those suffering from this condition. This blog aims to shed light on the benefits of this innovative combination therapy for chondromalacia patella.

Understanding Comprehensive Platelet Rich Plasma (PRP) with Prolotherapy

Before delving into the benefits, let’s briefly understand what Comprehensive Platelet Rich Plasma with Prolotherapy entails.

Platelet Rich Plasma (PRP) : PRP is an advanced regenerative therapy that harnesses the body\’s own healing abilities. It involves drawing a small amount of the patient’s blood, which is  processed by high speed centrifugation to concentrate platelets and growth factors(3,4) and then injecting this enriched plasma into the affected area. These growth factors promote tissue repair, reduce inflammation, and stimulate new tissue growth.

Prolotherapy : Prolotherapy, or proliferative therapy, is a complementary treatment that involves the injection of natural substances (often dextrose or saline) into weakened or injured ligaments or tendons. These injections provoke a localized inflammatory response, which activates the body’s natural healing processes, leading to tissue repair and strengthening(5-8)

The Synergy of Comprehensive PRP with Prolotherapy in Chondromalacia Patella

Now that we understand the components of this combination therapy, let’s explore the numerous benefits it offers for individuals dealing with chondromalacia patella.

Enhanced Healing and Regeneration : The combination of PRP and Prolotherapy works synergistically to accelerate the healing process. PRP provides a concentrated source of growth factors and cytokines that stimulate cell proliferation and tissue repair. When combined with Prolotherapy, the localized inflammatory response further promotes healing and the formation of new collagen fibers, enhancing the overall regenerative potential.

Reduction of Pain and Inflammation : Chondromalacia patella often leads to chronic knee pain and inflammation. Comprehensive PRP with Prolotherapy addresses this issue by not only promoting tissue repair but also reducing inflammation in the affected area. The growth factors in PRP possess anti-inflammatory properties, helping to alleviate pain and discomfort.

Non-Surgical Approach : One of the most significant advantages of Comprehensive PRP with Prolotherapy is that it is a non-surgical treatment option. For individuals reluctant to undergo surgery, this combination therapy offers a less invasive alternative with minimal downtime and a lower risk of complications.

Long-lasting Results : While conventional treatments may provide temporary relief, Comprehensive PRP with Prolotherapy aims to facilitate long-term healing. By promoting tissue regeneration and strengthening ligaments and tendons, this combination therapy can provide lasting benefits, reducing the likelihood of recurrence and allowing individuals to return to their activities with confidence.

Tailored Treatment : Every patient’s condition is unique, and Comprehensive PRP with Prolotherapy allows for personalized treatment plans. Physicians can adjust the concentration of PRP and the number of Prolotherapy injections based on the severity of chondromalacia patella and the patient’s specific needs, leading to more targeted and effective results.

Day Care Procedure and Shorter Recovery Time : As patient does not have to be admitted and can get back to routine activities within 3-4 days of the treatment, Prp and prolotherapy as a treatment is  way less demanding as opposed to surgery in terms of the morbidity of the treatment and the long period of guarded rehabilitation.

AT Alleviate

Patients usually undergo 3 sessions of Image guided  Platelet Rich Plasma with 5-6 sessions of Comprehensive Prolotherapy, followed by a structured physical therapy programme focussing on stretching and strengthening of the targeted muscle groups.


Comprehensive Platelet Rich Plasma with Prolotherapy presents a promising approach to managing chondromalacia patella. By harnessing the body’s natural healing mechanisms and promoting tissue regeneration, this combination therapy offers enhanced pain relief and improved functional outcomes for patients. As research in regenerative medicine continues to evolve, this innovative treatment option may revolutionize the management of not only chondromalacia patella but also other musculoskeletal conditions, providing hope and relief to countless individuals worldwide. If you are suffering from chondromalacia patella, it is essential to consult with a qualified healthcare professional to determine if Comprehensive PRP with Prolotherapy is the right solution for your unique needs.


  1. Mori Y, Kubo M, Okumo H, et al. Histological comparison of patellar cartilage degeneration between chondromalacia in youth and osteoarthritis in aging. Knee Surg Sports Traumatol Arthrosc. 1995;3(3):167-72.
  2. Brukner P. Anterior knee pain. In: Crossley K, Cook J, Cowan S, McConnell J, Eds. Brukner & Kahn’s Clinical Sports Medicine. 4th ed. Australia: McGraw-Hill, 2012. pp. 689-700.
  3. Kon E, Filardo G. PRP or not PRP?! That is the question. Knee Surg Sports Traumatol Arthrosc. 2011;19(6):870-1.
  4. Nguyen RT, Borg-Stein J, McInnis K. Applications of platelet-rich plasma in musculoskeletal and sports medicine: an evidence-based approach. PM R. 2011;3(3):226-50.
  5. Akpancar S, Seven MM, Tuzun HY, et al. Current concepts of prolotherapy in orthopedic surgery. Arch Trauma Res. 2017;6(2):e40447.
  6. Martins CAQ, Bertuzzi RT, Tisot RA, et al. Dextrose prolotherapy and corticosteroid injection into rat Achilles tendon. Knee Surg Sports Traumatol Arthrosc. 2012;20(10):1895-900.
  7. Rabago D, Lee KS, Ryan M, et al. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil. 2013;92(7):587-96.
  8. Seven MM, Ersen O, Akpancar S, et al. Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions. Orthop Traumatol Surg Res. 2017;103(3):427-33.

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